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An alternative to Urry's model for the gramicidin transmembrane channels (1991)

Lorenzi, Gian Paolo

New York, NY [u.a.] : Wiley-Blackwell

Chirality 3 (1991), S. 315-317

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ISSN: 0899-0042

Keywords: ↕ β6.3-model ; ↕ β-model ; ↕ β7.2-structures ; closed structures ; open structures ; non-conducting dimers ; Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: It is suggested that the conducting transmembrane channels formed by the linear gramicidins A, B and C may be head-to-head (formyl end-to-formyl end) dimers of double-stranded parallel β-helices. This possibility is not in conflict with any of the various experimental findings bearing on the molecular organization of the channels and represents a plausible alternative to Urry's model of a head-to-head dimer of single-stranded β6.3-helices.

Additional Material: 1 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/chir.530030416

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