ISSN:
0899-0042
Keywords:
ion channels
;
calcium channels
;
sodium channels
;
state-dependent interactions
;
voltage-dependent interactions
;
stereoselectivity
;
local anesthetics
;
calcium antagonists
;
1,4-dihydropyridines
;
verapamil
;
antifreeze proteins
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Ion channels are pharmacological receptors with specific drug binding sites. These binding sites define specific structure-function relationships for the actions of drug classes. Interpretation of these structure-function relationships may be complex because of state-dependent drug-channel interactions. These state-dependent interactions determine affinity and access of drug to binding sites and may result in both quantitative and qualitative changes in structure-function relationships including stereoselectivity. A channel-active drug may exhibit antagonist or activator properties according to membrane potential and the stereoselectivity of interaction may also change with channel state. © 1994 Wiley-Liss, Inc.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chir.530060204
