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Digitale Medien

Separation of R- and S-Thalidomide by Reversed-Phase HPLC with β-cyclodextrin in the mobile phase (1996)

Reepmeyer, John C.

New York, NY [u.a.] : Wiley-Blackwell

Chirality 8 (1996), S. 11-17

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Details

ISSN: 0899-0042

Schlagwort(e): thalidomide enantiomers ; mobile phase additive ; stereoselective analysis ; high-performance liquid chromatography ; chiral separation ; β-cyclodextrin ; inclusion complex ; Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: R- and S-Thalidomide were resolved by reversed-phase HPLC on a C-18 column with β-cyclodextrin in the mobile phase. As the concentration of β-cyclodextrin was increased stepwise from 0 to 20 mM, enantiomeric resolution increased and retention times decreased significantly. The influence of different organic modifiers in the mobile phase were evaluated, and ethanol, among others, proved to be effective. Equilibrium constants for the formation of β-cyclodextrin inclusion complexes of R- and S-thalidomide in EtOH-buffer (5:95) were calculated to be 64 and 76 M-1, respectively. © 1996 Wiley-Liss, Inc.

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

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