ISSN:
0899-0042
Keywords:
β-amino alcohols
;
enantiopure
;
chiral ligands
;
regioselective
;
stereoselective
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Both enantiomers of the important chiral β-amino alcohols erythro-2-amino-1,2-diphenylethanol were obtained via the separation of diastereoisomeric N-chlorinated derivatives of racemic trans-stilbene oxide and (S)-α-methylbenzylamine. The incorporation of chlorine in these precursors facilitated both the separation of diastereoisomers and the removal of the α-methylbenzyl chiral adjuvant. Each enantiopure β-amino alcohol was converted (Mitsunobu conditions) into the corresponding trans-2,3-diphenylaziridine in good overall yield. Chirality 10:95-99, 1998. © 1998 Wiley-Liss, Inc.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chir.16
