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Digitale Medien

A modulation of the anaphylactic basophil histamine release by selective H2 histamine agonists (1981)

Kazimierczak, Wacław ; Szczepaniak, Krystyna ; Bańkowska, Katarzyna

Springer

Inflammation research 11 (1981), S. 96-98

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Details

ISSN: 1420-908X

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Two selective H2-histamine agonists, dimaprit and impromidine, have been tested for their action on histamine release from human basophils and rat mast cells. IgE-mediated basophil histamine release was inhibited by stimulation of histamine H2-receptors. However, differences between the actions of both dimaprit and impromidine were noticed. Both impromidine and dimaprit had no specific effect on 48/80-induced histamine release from rat mast cells, although the latter in higher concentrations either slightly increased spontaneous histamine release or non-specifically inhibited compound 48/80-induced release. The results are consistent with the view that activation of adenylate cyclase via H2-histamine receptors might be an important regulatory mechanism of histamine release from human basophils but not from rat mast cells.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01991468

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