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T lymphocyte autoimmunity in peripheral nervous system autoimmune disease (1986)

Linington, C. ; Wekerle, H. ; Meyermann, R.

Springer

Inflammation research 19 (1986), S. 256-265

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ISSN: 1420-908X

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Conclusion Autoaggressive T cells specific for the PNS myelin P2 protein play a central role in the initiation of EAN in the Lewis rat, although there is as yet no direct experimental evidence that the T cells can themselves mediate demyelination in vivo. However, the striking similarities in the pathogenesis of EAN and the Guillain-Barré syndrome suggest that T cell mediated EAN provides an excellent model to study the immunological mechanisms of inflammation and demyelination that are relevant to human PNS disease.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01971223

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