ISSN:
1420-908X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We investigated thein vitro effects of increasing concentrations of three general anesthetics commonly used in clinical practice, i.e., ketamine (10−6–10−3 M), thiopentone (10−5–8×10−4 M) and propofol (5–70 μg/ml), on histamine release (HR) from human peripheral blood basophils and mast cells isolated from lung parenchyma (HLMC) and skin tissues (HSMC). None of the drugs induced HR from basophils. Ketamine caused HR from HLMC (p〈0.001 compared to spontaneous release [SR]) and HSMC (p〈0.05 compared to SR). Thiopentone induced limited HR from HLMC (p〈0.05 compared to SR). Propofol induced HR from HLMC (p〈0.005 compared to SR) and HSMC (p〈0.05 compared to SR). Thus, general anesthetics induce HR selectively from human mast cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01997330
