ISSN:
1420-908X
Keywords:
Papaverine salicylate
;
Croton oil
;
Cantharidin
;
Zymosan
;
PAF
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Papaverine salicylate (MR-800) has been tested as a topical antiinflammatory agent in several models of skin inflammation in rodents, such as mouse ear dermatitis induced by croton oil, cantharidin or zymosan, and rat paw oedema induced by PAF. MR-800 exerted a dose-dependent inhibitory activity in all assays, when equimolar doses of sodium salicylate or papaverine were less effective, suggesting the existence of a favourable synergism between salicylate and papaverine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02014296