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Digitale Medien

A new selective insecticidal uncoupler of oxidative phosphorylation (1986)

Holan, G. ; Smith, D. R. J.

Springer

Cellular and molecular life sciences 42 (1986), S. 558-560

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Details

ISSN: 1420-9071

Schlagwort(e): Lucilia cuprina ; sheep blowfly ; insecticides ; aryl hydrazone ; oxidative phosphorylation ; mitochondrial uncoupling

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary A new aryl hydrazone structure with high insecticidal activity against the Australian sheep blowfly,Lucilia cuprina, was shown to have a higher activity as an uncoupler of oxidative phosphorylation in insect compared to mammalian mitochondrial preparations. This compound possesses the requirements of other uncouplers in its measured pKa and lipid solubility. However, when compared to a closely related structure with similar physicochemical properties, its insecticidal and insect mitochondrial uncoupling activities are greater and it exhibits decreased mammalian toxicity corresponding to this differential biochemical selectivity.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01946702

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