ISSN:
1420-9071
Keywords:
Lectin
;
hemagglutinin
;
platelet
;
aggregation
;
inhibition
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Lectins from four marine algal species were examined for interaction with human platelets. The lectin designated hypnin A, from the red algaHypnea japonica, inhibited adenosine diphosphate (ADP)-or collagen-induced human platelet aggregation in a dose-dependent manner. Complete inhibition was observed at concentrations of 100 and 5 μg/ml of the lectin with, ADP (2 μM) and collagen (0.2 μg/ml)-induced platelet aggregation, respectively. At the inhibitory concentration of 0.5 to 100 μg/ml, the lectin did not induce aggregation of resting platelets. Lectins from the other three algal species also inhibited ADP-induced human platelet aggregation. These results indicate that the algal lectins are a new group of inhibitors and may be useful to study glycoconjugates on platelet membranes and to design novel platelet aggregation inhibitors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01969724
