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Production of rosmarinic acid from perfusion culture ofAnchusa officinalis in a membrane-aerated bioreactor (1991)

Su, Wei Wen ; Humphrey, Arthur E.

Springer

Biotechnology letters 13 (1991), S. 889-892

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ISSN: 1573-6776

Source: Springer Online Journal Archives 1860-2000

Topics: Process Engineering, Biotechnology, Nutrition Technology

Notes: Summary In this study, a perfusion fermentation ofAnchusa officinalis was carried out in a stirred tank bioreactor integrated with an internal cross-flow filter. Bubble-free aeration via microporous membrane fibers was used to provide oxygen. A two-stage culture was successfully conducted in this reactor without filter fouling. In a 17 day fermentation, a cell density of 26 g dw/I and a rosmarinic acid productivity of 94 mg/l day were achieved. This productivity is three times that obtained in a batch culture.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01022093

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