ISSN:
1573-3904
Keywords:
Amino acid fluoride
;
TPTU
;
Peptide-bond formation
;
Dialkyl amino acids
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Fmoc-O,O-(dimethylphospho)-l-tyrosine was converted into stable Fmoc-O,O-(dimethylphospho)-L-tyrosine fluoride by means of (diethylamino) sulfur trifluoride or cyanuric fluoride. This building block was used for efficient coupling of phosphotyrosine to the adjacent sterically hindered amino acid Aib or Ac6c in, model peptide sequences as well as for the synthesis of the ‘difficult’ phosphotyrosine peptide Stat91695–708. The phosphate methyl groups were cleaved on solid phase after peptide assembly by means of trimethylsilyl iodide in MeCN.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02443530