ISSN:
1573-501X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Libraries encoded with electrophoric tags present a uniquechallenge with respect to library quality control and characterization. Libraries are prepared on Tentagel resin in 200-fold redundancy wherein each resin particle containsone compound per one tag set. The amount of compound presenton the bead is ca. 200–500 pmole while tag levels are estimatedat 0.5–1 pmol/bead. Several quality control protocols have been developed in order to accurately estimate bead yield andpurity for the entire library, ensure high tag fidelity, andto determine the overall performance of individual synthons. This review provides a unique, collective portrait of Pharmacopeia's approach in assessing the quality of librariesprepared using its molecular encoding technology.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1011393414573
