ISSN:
1573-7446
Keywords:
albendazole
;
metabolites
;
pharmacokinetics
;
route of administration
;
sheep
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The pharmacokinetics of albendazole was studied in sheep following single oral and intraruminal administration at nematocidal dose rates. The disposition curves of its metabolites indicated increased uptake of the drug in sheep following intraruminal as compared to oral dosing (p〈0.05). The increased bioavailability of benzimidazole anthelmintics given by the intraruminal route could be exploited for optimizing the use of anthelmintic for sustained parasite control in small ruminants.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1006145820818