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Renal eicosanoids and blood pressure in genetically hypertensive rats of the lyon strain (1994)

Sassard, Jean ; Benzoni, Daniel

Springer

Journal of biomedical science 1 (1994), S. 201-203

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ISSN: 1423-0127

Keywords: Hypertension ; Eicosanoid ; Rat ; Genetics ; Kidney

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract The present paper reviews the evidence for a possible involvement of renal eicosanoids in the pathophysiology of high blood pressure in genetically hypertensive rats of the Lyon strain. Both in vivo and in vitro experiments suggest that an increased ability to synthesize the vasoconstrictor prostaglandin H2 and/or thromboxane A2 in renal vessels (1) acts as an autocrine amplifier of pressor agents and (2) may contribute to resetting the pressure natriuresis curve which is a prerequisite for the development and maintenance of hypertension.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02253302

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