ISSN:
1824-3096
Keywords:
Human serum cholinesterase
;
Suecinylcholine sensitivity
;
Population study
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract 392 random patients treated with SCC prior to surgery were assayed for pseudocholinesterase activity and electrophoretic pattern. The estimate of the percent frequencies of theE 1 a allele were 1.16±0.38 and of the C5 (+) phenotype 9.7±1.5, both typical of Caucasian populations. By combining the presentE 1 a gene frequency estimate with that from another sample of the same population (Cermele et al., 1987) a better estimate with smaller confidence limits was obtained, that is: 1,14±0,27. One subject interpreted asE 1 a E 1 a on phenotypic grounds was also found (expected 0,05) in this random sample. A correlation coefficient of −0.521 was found between E activity and myorelaxation time in the whole sample. High correlation values (r=−0.55 and r=−0.46) were found forE 1 u E 1 u ; C5 (−) andE 1 u E 1 u ; C5 (+) individuals, respectively, showing a strong dependence of the latter variable on the former one even within apparently homogeneous classes. The use of the product of these two variables as a classification criterion allowed the identification of a subject with very long myorelaxation time but normal activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02442073