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Digitale Medien

Toxicological study of king crab collagenase (1995)

Glyantsev, S. P. ; Savvina, T. V. ; Litvin, F. E. ; [weitere]

Springer

Bulletin of experimental biology and medicine 119 (1995), S. 377-380

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Details

ISSN: 1573-8221

Schlagwort(e): collagenase ; king crab ; toxicology ; blood components ; liver ; kidneys

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Abstract A toxicological study of a preparation of king crab collagenase designed for local treatment of wounds shows that daily hypodermal administration of various concentrations of preparation (1.5 to 15 mg/ml) over 5 days does not affect erythrocyte morphology or hemoglobin content in laboratory animals (rats and rabbits). Systemic enzyme administration does not alter the histological structure of the kidneys (kidney is the target organ for enzyme) but leads to dose-dependent reversible degeneration of rat liver tissues. The milder effects of the preparation in comparison with a comparable dose of the widely used chymopsin affirm that this collagenase preparation is suitable for external use.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02445898

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