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Estimation of transmembrane potential of thymic lymphocytes during dexamethasone-induced apoptosis (1999)

Dukhanin, A. S. ; Patrashev, D. V.

Springer

Bulletin of experimental biology and medicine 127 (1999), S. 106-109

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ISSN: 1573-8221

Keywords: apoptosis ; transmembrane potential ; glucocorticoids ; thymocytes

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract The use of potential-sensitive fluorescent probes allowed us to estimate transmembrane potentials of the plasma (Δφp) and mitochondrial (Δφm) membranes of rat thymocytes, which were −58±3 mV and −169±7 mV, respectively. Dexamethasone-induced apoptosis led to a significant decrease in Δφp (by 55%) and Δφm (by 17%). This effects of dexamethasone was dose- and time-dependent. Changes in Δφm were greater and preceded those in Δφp.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02432815

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