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Digitale Medien

Effect of morphine in vitro on oxidative phosphorylation in rat liver mitochondria (1975)

Gegenava, G. P. ; Chistyakov, V. V.

Springer

Bulletin of experimental biology and medicine 80 (1975), S. 1218-1220

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Details

ISSN: 1573-8221

Schlagwort(e): liver mitochondria ; oxidative phosphorylation ; ATPase ; morphine

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Abstract Experiments in vitro on rat liver mitochondria showed that morphine inhibits oxidation of substrates in the presence of ADP and reduces the rate of phosphorylation and the activity of dinitrophenol-stimulated ATPase. The inhibition constant for all these reactions is the same, namely 6.5 mM. Respiration of mitochondria in the presence of an uncoupling agent and also the activity of ATP synthetase and ATPase of the submitochondrial particles are not inhibited in the presence of morphine. It is postulated that morphine inhibits the transfer of adenine nucleotides across the mitochondrial membrane.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00833166

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