ISSN:
1573-4927
Keywords:
glucose-6-phosphate dehydrogenase
;
Michaelis constants
;
G6PD Porbandar
;
South African Indian
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract A new variant of the red cell enzyme glucose-6-phosphate dehydrogenase has been detected in a South African male of Indian descent and in several of his relatives. The enzyme variant is characterized by slow electrophoretic mobility, low Michaelis constants for the substrates glucose-6-phosphate and NADP, and increased utilization of the substrate analogues 2-deoxyglucose-6-phosphate and deamino-NADP relative to the normal (B+) enzyme. There is no evidence that the enzyme variant, for which the name “G6PD Porbandar” is suggested, is associated with any hematological abnormality.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00484102