ISSN:
1573-2568
Keywords:
nicotine
;
ethanol-induced gastric mucosal injury
;
NG-nitro-l-arginine methyl ester
;
adrenal medullectomy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We tested the hypotheses that the protective effect of intragastric nicotine against ethanol-induced gastric mucosal injury is dependent on endogenous nitric oxide or peripheral sympathoadrenal mechanisms. Rats were pretreated with NG-nitro-l-arginine methyl ester (3 mg/kg subcutaneous, 1 h prior to study) to block endogenous nitric oxide synthesis or with adrenal medullectomy (three weeks prior to study) to ablate the effect of the adrenal medulla. At 1-h intervals, vehicle or nicotine (4 mg/kg) and 40% ethanol were then given intragastrically. The total lengths of the linear gastric corpus mucosal lesions were measured unbiasedly. The protective effect of intragastric nicotine was not modified by either pretreatment. We conclude that the mechanism mediating intragastric nicotine protection against 40% ethanol-induced gastric mucosal injury is independent of endogenous nitric oxide or the adrenal medulla.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02090207
