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Short communication: Cause and prevention of mafosfamide-induced venous pain (1986)

Hilgard, Peter ; Pohl, Jörg

Springer

Investigational new drugs 4 (1986), S. 373-376

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ISSN: 1573-0646

Keywords: acrolein ; mafosfamide ; mesna ; N-acetyl-cysteine ; oxazaphosphorines ; venous pain

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Abstract An experimental rat model for the study of venous pain induced by 4-hydroxy-cyclophosphamide (4-OH-CP) derivatives was developed and validated. Using various metabolites and chemical variants of 4-OH-CP it was found that pain induction was independent from the compound's alkylating activity but possibly related to the spontaneous generation of minute amounts of acrolein from the 4-OH-CP molecule. Accordingly, the pain could be prevented by the addition of thiol compounds such as mesna or N-acetyl-cysteine.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00173510

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