ISSN:
1572-8854
Source:
Springer Online Journal Archives 1860-2000
Topics:
Geosciences
,
Physics
Notes:
Abstract The crystal stucture of a synthetic monoquaternary azasteroid containig an acetylcholine-like moiety, 17a-(2-acetoxyethyl)-17a-aza-d-homo-5 androsten-3β-yl-acetate methiodide (HS465) (C26H42NO4)+I−, has been determined by the heavy-atom method and refined by full-matrix least squares toR=0.0410 for 2462 reflections, using MoKα radiation (λ=0.7114 Å). The crystals are monoclinic:P21,a=15.244(4),b=9.009(6),c=9.886(3) Å,β=104.26°(3),Z=2. RingsA andC have distorted-chair conformations, ring d-homo is a symmetrical chair, and ringB is a half-chair. The acetoxyethyl side-group appended to N(17a) simulates an acetylcholine-like moiety, and exhibits a conformation similar to that frequently adopted by acetylcholine itself in the presence of heavy anions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01161111