ISSN:
1572-8854
Source:
Springer Online Journal Archives 1860-2000
Topics:
Geosciences
,
Physics
Notes:
Abstract The crystal structure of 4,17a-di(2-hydroxyethyl)-4,17a-diaza-d-homo-5α-androstane, C22N2O2H40 (HS461), the tertiary amine related to HS781, a potential bisquaternary neuromuscular blocking agent, has been determined by direct methods and refined by full-matrix least squares toR=0.0867 for 2049 reflections (R=0.0597), CuKα radiation θ≦65°. The space group is P212121 a=20.295(4),b=7.278(6),c=14.052(4) Å,Z=4. The rings in the modified steroid nucleus are alltrans connected symmetrical chairs. Hydroxyethyl side groups at N(4) and N(17a) both have an equatorial disposition, and the side chains assumetrans conformations.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01179835