ISSN:
1573-8744
Keywords:
drug clearances
;
perfusion models
;
isolated perfused organ systems
;
pharmacokinetic clearance
;
steady-state clearance
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The kinetics of a drug eliminated by first-order processes in a perfusion-limited isolated perfused organ system are examined. In this model, the mean clearance, determined by dividing the dose by the area under the blood concentration profile, and the steady-state clearance are shown to be equal. The perfusion model and the compartmental model are compared and contrasted. Effects of blood flow and reservoir size on drug clearance are examined. Similarities and differences between the isolated and the in vivoorgan system are explored. The virtue of using clearance, instead of half-life, as a correlative parameter between these systems is stressed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01059626
