ISSN:
1573-8744
Keywords:
pharmacokinetics
;
nonlinear regression
;
drug distribution
;
compartmental models
;
computer program
;
BASIC
;
time sharing
;
spectinomycin
;
naloxone
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract COMPT, a computer program for optimizing the solution of integral compartmental models of drug distribution by nonlinear regression analysis, is written in extended BASIC for use in time-sharing computer systems. It is based on Hartley's modification of the Gauss-Newton gradient method. The characteristics and features of the program are indicated, and the program source listing is presented. This version of COMPT is designed to solve the two-compartment open model of intravenous drug administration. Examples of the results of the operational program are presented. The program is modifiable to permit analytical solutions for other types of systems described by nonlinear equations.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01059627
