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Rapid Attainment of Steady-State Plasma Drug Concentrations Within Precise Limits in Multicompartment Mammillary Systems (1999)

Korman, Ben ; Jennings, Les S.

Springer

Journal of pharmacokinetics and pharmacodynamics 27 (1999), S. 325-328

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ISSN: 1573-8744

Keywords: anesthetic techniques ; continuous infusion ; pharmacokinetics

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract We have previously described a method of rapidly obtaining a specified steady-state plasma concentration of an intravenous drug within precise limits. However the method is limited to drugs whose disposition may be characterized by an open two-compartment system. In this paper, we illustrate how the method can be extended to drugs whose disposition may be characterized by a mammillary model with any number of compartments. Refinements of our previous technique are also described.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1020951230947

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