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Importance of assay specificity for plasma protein binding determinations (1975)

Yacobi, Avraham ; Levy, Gerhard

Springer

Journal of pharmacokinetics and pharmacodynamics 3 (1975), S. 439-441

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ISSN: 1573-8744

Keywords: protein binding ; equilibrium dialysis ; ultrafiltration ; warfarin

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract Plasma or serum protein binding determinations of extensively bound drugs are subject to serious error if the analytical methods employed do not discriminate between such drugs and their degradation products, metabolites, and impurities. Experimental evidence is presented to demonstrate the magnitude of this problem with respect to warfarin.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01059475

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