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Digitale Medien

Effect of Nitric Oxide Donors on GABA Uptake by Rat Brain Synaptosomes (1997)

Cupello, A. ; Mainardi, P. ; Robello, M. ; [weitere]

Springer

Neurochemical research 22 (1997), S. 1517-1521

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Details

ISSN: 1573-6903

Schlagwort(e): Nitric oxide ; GABA ; uptake ; synaptosomes

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The effect of nitric oxide donors and L-arginine on the uptake of GABA was studied in synaptosomes purified from rat brain. The neurotransmitter uptake was significantly reduced by S-nitrosoacetylpenicillamine and by sodium nitroprusside, although in this case to a lesser extent. A slight inhibitory effect was found preincubating rat brain synaptosomes with 1 mM L-arginine as well. The S-nitrosoacetylpenicillamine effect gradually disappeared with decomposition of the substance by exposure to light. The nitric oxide effect appears to be mainly due to a decrease in the V for synaptosomal GABA uptake and seems to be related to a partial collapse of nerve endings ionic gradients. Functionally, it could result over time in a reduced availability of GABA at the synapses involved.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1023/A:1021966814942

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