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Thermal Stability of Mefruside–Polyvinylpyrrolidone Solid Dispersions (1986)

Junginger, Hans E. ; Wedler, Michael

Springer

Pharmaceutical research 3 (1986), S. 41-44

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ISSN: 1573-904X

Keywords: mefruside ; thermal stability ; solid dispersions ; polyvinylpyrrolidone

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract The stability of mefruside–polyvinylpyrrolidone (PVP) 30 solid dispersions at ratios of mefruside/PVP 30 of 9/1, 7/3, and 5/5 (g/g) after mechanical (tableting) and allothermic stressing (50, 60, and 70°C up to 240 hr) was investigated. Only the 5/5 (g/g) solid dispersion showed no recrystallization of mefruside, whereas a slight increase in crystallinity in the 7/3 (g/g) solid dispersion and a strong increase in the 9/1 (g/g) product were detected. The mechanisms of drug recrystallization in such “high-energy products” are discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1016320831469

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