ISSN:
1573-904X
Keywords:
steady-state analysis
;
unsteady-state analysis
;
USP XXI hydrophilic ointment
;
phase–volume ratio
;
1% anthralin products
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The objective of this paper is to determine oxygen diffusion coefficients, permeabilities, and solubilities in a commonly used o/w topical ointment (similar to USP XXI hydrophilic ointment) and four commercial 1% anthralin creams. A new method developed by Ju and Ho in 1986 by applying a coupled steady-state and unsteady-state analysis for oxygen diffusion through a thin layer of test material on the surface of a membrane-covered polarographic oxygen electrode was used in the study. The results indicate that oxygen diffusion coefficients decrease with an increasing petrolatum concentration in o/w topical creams. The oxygen diffusion coefficients in four commercial creams containing 1% of extremely oxygen-sensitive anthralin were also determined using the same method. The information generated in this study can lead to a better understanding of the diffusion transport mechanism of oxygen in the topical creams and, thus, be useful to the formulation design of oxygen-sensitive drugs in semisolid dosage forms intended for topical, ophthalmic, and parenteral use.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015936100750
