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  • 1
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In 8 patient with recently discovered spontaneous hypothyroidism decreased assimilation of glucose was found despite marked hyperinsulinism in the fasting state and following glucose administration. In contrast, in hypothyroidism due to thyroidectomy in both decreases in peripheral glucose assimilation and plasma insulin concentrations before and after glucose stimulation were established. The different behaviour of spontaneous and reactive insulin secretion in the two different types of myxedema remains open to discussion. In any case, treatment with thyroid hormones results in normalization of glucose utilization and insulin secretion.
    Notes: Zusammenfassung Bei 8 Patienten mit frisch entdeckter, spontan aufgetretener unbehandelter Hypothyreose wurden Glucoseassimilation und Insulinsekretion geprüft und mit der von 200 Normalpersonen verglichen. Die Glucoseassimilation war bei den Hypothyreoten vermindert, der Seruminsulinspiegel in Ruhe und nach Belastung jedocherhöht. Dieser Befund spricht für eine Beeinträchtigung der Glucoseassimilation in der Peripherie. Patienten, bei denen die Hypothyreose nach einer Strumektomie aufgetreten ist, zeigen ebenfalls eine schlechte Glucoseassimilation, jedoch eineverminderte Insulinsekretion in Ruhe und nach Belastung. Unter Behandlung mit Schilddrüsenhormonen lassen sich Glucoseassimilation und Insulinsekretion normalisieren.
    Type of Medium: Electronic Resource
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