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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 56 (1978), S. 309-310 
    ISSN: 1432-1440
    Keywords: Perhexilin-Maleat ; generalisierte Lipidose ; Ratte ; Perhexiline maleate ; Generalized lipidosis ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Administration of perhexiline (Pexide®) to rats causes generalized occurrence of lamellated and crystalloid cytoplasmic inclusions which resemble those described in patients with perhexiline-induced polyneuropathy. It is concluded that perhexiline being an amphiphilic cationic compound is a potent inducer of generalized lipidosis.
    Notes: Zusammenfassung Perhexilin (Pexid®) verursacht bei der Ratte das generalisierte Auftreten von lamellären und kristalloiden zytoplasmatischen Einschlußkörpern, die denjenigen gleichen, die bei Patienten mit Perhexilin-induzierter Polyneuropathie beschrieben worden sind. Aus den vorgelegten Befunden wird geschlossen, daß Perhexilin, eine amphiphile kationische Verbindung, ein starker Induktor einer generalisierten Lipidose ist.
    Type of Medium: Electronic Resource
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