ISSN:
1432-0428
Keywords:
Islet hyperplasia
;
islet DNA
;
islet protein
;
insulin release
;
tolbutamide treatment
;
theophylline
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Following prolonged administration of tolbutamide the DNA- and protein content per islet was enhanced but the IRI content per islet was diminished. Glucose-induced (2.0,8.0 or 16.6 mM) and leucine-induced (12.5 or 25.0 mM) IRI release from isolated islets, as well as 14CO2-production from U-14C glucose, were decreased. Theophylline (5.0 mM) restored the glucose sensitivity of the islets towards normal. The results indicate that tolbutamide-induced islet cell hyperplasia does not entail islet hyperfunction, as previously thought. Decreased IRI release may partially be explained by a tolbutamide-induced alteration of the adenylate cyclase/phosphodiesterase system of the B-cell.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00422395
