ISSN:
1432-0428
Keywords:
Hyperglycaemia
;
hyperinsulinaemia
;
genetically diabetic KK mice
;
epinephrine
;
isoproterenol
;
α-adrenergic antagonist
;
β-adrenergic antagonist
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Simultaneous occurrence of hyperglycaemia (up to 300 mg/100 ml) and hyperinsulinaemia (up to 1200 μU/ml) was evident in the fed state in genetically diabetic KK mice, indicating insulin resistance. The hyperinsulinaemia was enhanced by α-adrenergic blockade and alleviated by B-blockade. Epinephrine-induced hyperglycaemia and isoproterenol-induced hyperinsulinaemia, both of which could be blocked by β-adrenergic antagonists, were more marked in KK mice than in ICR mice. A possible significance of adrenergic mechanisms is discussed with respect to the aetiology of the metabolic disturbances characteristic of KK mice.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00252767
