ISSN:
1432-0428
Keywords:
Streptozotocin diabetes
;
blood-nerve barrier
;
non-enzymatic glycation
;
serum proteins
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The permeation of native and non-enzymatically glycated albumin and immunoglobulin G into the endoneurium of the sciatic nerve of rats was examined in acute experiments. Low amounts of native albumin entered both in control and streptozotocin-diabetic animals with no significant difference between them. The entry of glycated albumin was significantly greater both in control and diabetic rats, especially in the former. Permeation of native and glycated immunoglobulin G was not detectable over the time course of the experiment. It is concluded that glycation of albumin enhances its permeation into the nerve. This may be relevant to the increased amounts of endoneurial albumin that are detectable in human diabetic neuropathy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00500376
