ISSN:
1432-1238
Keywords:
Key words Critical illness
;
Systemic inflammatory response syndrome
;
Infection
;
Sepsis
;
Granulocyte colony-stimulating factor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Objective: To evaluate the effect and safety of a low dose Filgrastim treatment in surgical intensive care patients. Design: Prospective, clinical study. Setting: Surgical intensive care unit (ICU) in a university hospital. Patients: Ten patients with the systemic inflammatory response syndrome (SIRS) and ten patients with sepsis were included in the study. Interventions: Filgrastim was given intravenously at 1.0 μg/kg for 3 days, followed by 0.5 μg/kg for 4 days. Measurements and results: Filgrastim treatment increased leukocyte counts and plasma levels of G-CSF. Cytokine levels (IL-6 and IL-8) decreased in the first 3 days of treatment. None of the SIRS patients developed sepsis or multiple organ failure and none of the patients died. In the sepsis group four patients died. No adverse side effects were observed, especially no attenuation of lung injury. Conclusions: Low-dosage Filgrastim treatment in ICU patients is safe. Whether the observed changes of the inflammatory response can be attributed to Filgrastim has to be clarified in further randomized trials.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001340050285
