ISSN:
1432-2277
Keywords:
Key words Combined liver-kidney transplantation
;
Positive crossmatch
;
Lymphocytotoxic antibodies
;
Long-term follow up
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Since August 1992, 18 patients underwent combined liver and kidney transplantation. Eight patients had lymphocytotoxic antibodies pretransplant and 5 of these patients (27.7%) had a positive crossmatch. Fifteen patients received cyclosporine-based immunosuppression and 3 patients were treated with a tacrolimus-based immunosuppressive protocol. One patient died in the postoperative course due to intractable bleeding episodes after 96 days and one kidney graft was lost due to technical complications. The 1-year survival rate of patients with combined transplantation was 95% vs 87% in patients with liver transplantation alone. None of the patients with a positive crossmatch experienced a hyperacute rejection of the kidney. The long-term patient and graft survival was not impaired in patients with a positive crossmatch. These results suggest that combined liver-kidney transplantation is a safe treatment for end-stage liver and renal disease. A positive crossmatch or positive lymphocytotoxic antibodies are not contraindications for a combined transplantation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001470050450
