ISSN:
1432-072X
Keywords:
Key words Fungal naphthoquinones
;
Respiratory
;
burst
;
Superoxide anion
;
Electron acceptor
;
Antibacterial activity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The mechanism of action of antimicrobial naphthoquinones from the fungus Fusarium was studied by using Pseudomonas aeruginosa. Bostricoidin, methyl ether fusarubin, and fusarubin stimulated the oxygen consumption of bacterial cells and induced cyanide-insensitive oxygen consumption. These activities of the tested compounds were also observed in bacterial membrane preparations in a dose-dependent manner. Naphthoquinones stimulated the generation of superoxide anion and hydrogen peroxide. The naphthoquinone effectively acted as the electron acceptors for bacterial diaphorase, which could explain the antibacterial activity of Fusarium naphthoquinones since electron acceptors lead to the stimulation of respiratory activity and the generation of oxygen radical species.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002030050409
