ISSN:
1432-0738
Keywords:
Ascorbic acid
;
Free radicals
;
Electron spin resonance
;
Paraquat
;
Pyridinium compounds
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract To clarify the toxicological mechanism of action of paraquat and diquat, the level of ascorbate radical, an oxidized product of ascorbic acid, was examined using the electron spin resenance (ESR) method. The ascorbate radiacal level increased to twice the normal level in sera from humans acutely intoxicated with a 1∶1 mixture of paraquat and diquat, and to more than 1.5 times the normal level in rat plasma containing moderate levels of paraquat. The dosage level for rats was 0.025% paraquat dichloride in the diet. The ascorbate radical in both intoxicated human sera and rat plasma decayed much faster than that in normal samples
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01973683
