ISSN:
1432-2072
Schlagwort(e):
Opioids
;
Stress
;
Anxiety
;
Rat
;
Benzeneacetamides
;
H-50,488H
;
U-69,593
;
Naloxone
;
Open field
;
Spontaneous locomotor activity
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract The selectivek agonist U-50,488H was evaluated on the elevated plus-maze test of anxiety. U-50,488H was administered intraperitoneally to male Sprague-Dawley rats 20 min before testing, first in an open field apparatus, then followed immediately on the elevated plus-maze. No significant change in spontaneous locomotor activity was measured in the open field apparatus, suggesting that U-50,488H was devoid of sedative effects in the dose range tested (0.1–1000 µg/kg, IP). Doses between 10 and 1000 µg/kg produced significant increases in elevated plus-maze behavior that were consistent with anxiolytic actions for U-50,488H. These anxiolytic-like effects were antagonized by naloxone (2.0 mg/kg, IP), suggesting an opioid receptor site of action. In addition, we tested thek 1-selective U-50,488H-derivative, U-69,593 (100 µg/kg, IP), which was also shown to mimic the anxiolytic-like effects produced by U-50,488H. These results suggest that low doses of the selectivek 1 agonists U-50,488H and U-69,593 are endowed with anxiolytic properties in rodents and that thek opioid system may be involved in the behavioral response to anxiety.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02245945
