ISSN:
1432-1041
Keywords:
benzbromarone
;
benzarone
;
blood levels
;
pharmacokinetics
;
biotransformation
;
excretion
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary After administration of a single oral dose of benzbromarone 100 mg to 7 subjects, the maximum serum level was 1.84±0.87 mg/l, and the elimination halflife was 2.77±1.07 h. The major metabolite, benzarone, could be detected in serum 3 h after administration of benzbromarone, and the maximum serum benzarone level of 0.79±0.21 mg/l occurred after 6 h. Benzarone had an elimination half-life from serum of 13.52±2.18 h. Both substances were excreted mainly via the liver and bile. In urine only benzarone β-glucuronide could be detected; it amounted to 1.55% of the benzbromarone dose.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00548587
