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Digitale Medien

Family study of genetic and environmental factors determining the protein binding of propranolol (1983)

Alván, G. ; Bergström, K. ; Borgå, O. ; [weitere]

Springer

European journal of clinical pharmacology 25 (1983), S. 437-441

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Details

ISSN: 1432-1041

Schlagwort(e): propranolol ; protein binding ; genetic factors ; environmental factors ; plasma orosomucoid ; plasma albumin

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary The unbound fraction of propranolol was found to vary from 1.9 to 13.2% in 434 plasma samples from members of 132 families. As expected, there was a linear correlation between the ratio of bound/unbound propranolol and the orosomucoid concentration (r=0.67, P〈0.001). Albumin concentration did not influence propranolol binding. The unbound fraction was negatively correlated with obesity and alcohol intake, but was not significantly influenced by age and sex. By applying path analysis, 21% of the variability in propranolol binding could be ascribed to genetic factors and 5% to common environmental factors.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00542107

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