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Lack of effect of astemizole on ethanol dynamics or kinetics (1983)

Bateman, D. N. ; Chapman, P. H. ; Rawlins, M. D.

Springer

European journal of clinical pharmacology 25 (1983), S. 567-568

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ISSN: 1432-1041

Keywords: astemizole ; ethanol ; antihistamine ; pharmacodynamics ; pharmacokinetics

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The effects of astemizole (10 mg daily for 7 days) on the kinetics and CNS depressant activity of ethanol have been examined in a double-blind cross-over study agonist placebo in 7 volunteers. There was no significant change in the elimination rate or AUC of the plasma ethanol concentration-time curve after astemizole. Central nervous system effects of ethanol as monitored by visual analogues of sedation, visual discrimination, pursuit rotor and reaction time were also unaffected by astemizole pretreatment.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00542130

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