ISSN:
1432-1041
Keywords:
nadolol
;
pharmacokinetics
;
plasma levels
;
urinary excretion
;
bioavailability
;
circadian rhythm
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary In 7 healthy subjects (3 males and 4 females), the kinetics of nadolol was investigated after oral doses of 60 and 120 mg. The t1/2 was 14.0±1.8 h. The peak plasma level was doubled on doubling the dose (from 69±15 to 132±27 ng/ml, respectively) and the urinary excretion (13.5%) rose similarly. The half-life of elimination was longer at night than in the day, probably because of the slower nocturnal flow of urine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00546720