ISSN:
1432-1041
Keywords:
guar gum
;
drug absorption
;
dietary fibre
;
digoxin
;
penicillin
;
serum concentration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The effect of guar gum on the absorption of digoxin and phenoxymethyl penicillin was studied in a double blind study in 10 healthy volunteers. Guar gum reduced serum digoxin concentration during the early absorption period, but a similar amount of digoxin was found in 24 h urine whether given with or without guar gum. Both the peak penicillin concentration and the area under the serum curve were significantly reduced by the gum.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00630301