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  • 1
    Electronic Resource
    Electronic Resource
    Evaluation of a sustained release form of the oral antidiabetic butylbiguanide (Silubin® retard) (1971)
    Springer
    European journal of clinical pharmacology 3 (1971), S. 221-228 
    Details
    ISSN: 1432-1041
    Keywords: Biguanides ; butylbiguanide ; pharmacokinetics ; sustained release form
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In man, after oral administration of 50 mg14C-butylbiguanide, the maximum serum concentration was 26–41 µg/100 ml. The biguanide was eliminated with an average half-life of 2h. 84% of the dose administered was found excreted unchanged in the urine. — After administration of14C-butylbiguanide in a sustained release form (Silubin® retard), the drug was slowly released and its serum concentration remained almost constant for up to 7 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00565010
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