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5-Hydroxyindoleacetic acid in cerebrospinal fluid of patients with Parkinson's syndrome treated with L-DOPA (1971)

Johansson, B. ; Roos, B. E.

Springer

European journal of clinical pharmacology 3 (1971), S. 232-235

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ISSN: 1432-1041

Keywords: Parkinsonism ; 5-hydroxyindoleacetic acid ; cerebrospinal fluid ; L-DOPA ; homovanillic acid

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary 5-Hydroxytryptamine (5-HT) turnover has been studied in eleven patients with Parkinson's disease before and during L-DOPA administration, using a test based on the fact that probenecid inhibits the active transport of acid monoamine metabolites, such as 5-hydroxyindoleacetic acid (5-HIAA), from cerebrospinal fluid to blood. A significant decrease in 5-HT turnover was observed during L-DOPA treatment, and possible mechanisms for it are discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00565012

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