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The pharmacokinetics of clotiazepam after oral and sublingual administration to volunteers (1989)

Benvenuti, C. ; Bottà, V. ; Broggini, M. ; [et al.]

Springer

European journal of clinical pharmacology 37 (1989), S. 617-619

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ISSN: 1432-1041

Keywords: clotiazepam ; pharmacokinetics ; healthy volunteers

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary We have studied the single dose pharmacokinetics of 5 mg clotiazepam drops, oral tablets, and sublingual tablets in a cross-over study in 6 healthy volunteers (median age 28 years). The formulations had similar systemic availability. Compared with oral tablets the sublingual route gave a lower peak concentration and a delayed peak time, while drops gave a greater maximum concentration with a similar peak time. The use of drops is suggested for a more marked initial effect and the sublingual route for easier administration, especially in the elderly.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00562556

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