ISSN:
1432-1041
Keywords:
Key words Cicletanine
;
Tolbutamide; drug interaction
;
healthy volunteers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Objective: To determine the possible interaction between the antihypertensive agent cicletanine and the hypoglycaemic drug tolbutamide. Methods: Time-courses of glycaemia and serum immunoreactive insulin (IRI) were followed in 10 healthy subjects after two tolbutamide infusions in each volunteer: initially alone and 9 days later concomitantly with repeated oral cicletanine. Any drug interaction was quantified on the basis of a decrease or increase in the AUC with time of glycaemia and IRI by subtraction of baseline concentration (AUC0 240-GLY and AUC0 60-IRI). Peak glycaemia and peak IRI, and the corresponding time to peaks, were also assessed. Results: Following tolbutamide, mean AUC0 240-GLY values were 97.7 and 98.8 mmol⋅l−1⋅min, without or with cicletanine, respectively; the corresponding AUC0 60-IRI were 485 and 321 mU⋅l−1⋅min. Mean peak glycaemia values were 0.996 and 1.071 mmol⋅l−1. Regarding the peak IRI, a decrease was observed after tolbutamide and cicletanine: median values were 29.2 and 17.4 mU⋅l−1. The corresponding median time to peak of glycaemia and IRI values were 30 and 30 min, and 5 (all subjects) and 5 min. Conclusion: No clinically relevant interaction was shown after the concomitant administration of repeated oral doses of cicletanine and acute intravenous tolbutamide to healthy volunteers.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002280050127
